Parkinson’s and Regenerative Medicine: The Beginning of a New Hope

Written by Dr. Joe Díaz

What is it?

Parkinson’s disease is an extrapyramidal neurodegenerative syndrome. It is characterized primarily by muscle rigidity, which can be observed as resistance to passive movements; resting tremor, which can worsen in situations of anxiety; and bradykinesia, that is, slowness in initiating and completing movements. These symptoms affect balance, causing an unsteady gait and hunched posture.

Causes

To date, no single cause of the disease has been identified. It is considered to be the result of a combination of genetic and environmental factors.
At the physiological level, the disease involves dysfunction in the basal ganglia, key brain structures for motor control and cognition. This dysfunction is due to a decrease in dopamine levels, a neurotransmitter essential for the transmission of nerve impulses and motor coordination. A lack of dopamine generates abnormal activity in certain regions of the brain, resulting in involuntary movements and lack of motor control.

Clinical characteristics

Parkinson’s disease presents primarily motor symptoms. Resting tremor is usually the first visible sign, followed by rigidity and akinesia (absence of movement).
Over time, non-motor manifestations are added, which have gained relevance in recent years. These include apathy, depression, and sleep disorders, which tend to worsen as the disease progresses. The diagnosis of Parkinson’s disease is clinical, based on observation of the patient’s symptoms and progress. Although there are no specific tests to confirm it, the specialist’s judgment is key in identifying the disorder.

New frontiers of treatment

In recent decades, research has focused not only on alleviating symptoms but also on directly intervening in the cellular processes responsible for the disease. In this context, regenerative medicine has opened up a promising field. The so-called neuroregenerative peptides are small molecules made up of short chains of amino acids. Thanks to their structure, they can cross biological barriers such as the blood-brain barrier, allowing direct action on the central nervous system. Once there, they activate biochemical processes that stimulate neuroplasticity: the brain’s ability to reorganize and form new neuronal connections.

“Little regenerative giants”

Neuroregenerative peptides represent a new therapeutic hope for chronic and debilitating diseases such as Parkinson’s. Their ability to act at the cellular level makes them a potentially transformative tool.

One of them is Epitalon, which acts at the epigenetic level by stimulating the enzyme telomerase, responsible for repairing and lengthening telomeres (structures that protect DNA and regulate cellular longevity). It also reduces oxidative stress by reducing free radicals, which protects cells, reduces inflammation, and promotes cell renewal, including neurons.

Another notable compound is Semax, which acts directly on the central nervous system, especially the midbrain. It regulates dopamine and serotonin levels and stimulates neurotrophic factors such as BDNF (brain-derived neurotrophic factor), promoting neuronal plasticity and the growth of new neurons. Patients treated with Semax have observed improvements in memory, mood, sleep, and motor coordination.

Also worth mentioning is Selank, a peptide that acts on various neurochemical systems,
particularly by modulating the GABA system, the brain’s main inhibitory neurotransmitter.
Selank has anxiolytic effects, reduces stress, improves concentration and learning, and
reduces levels of neuroinflammation.

Rewriting the destiny of the brain

Regenerative medicine is marking a turning point in the approach to Parkinson’s disease. By
stimulating the brain’s natural ability to renew itself, it opens up paths that previously seemed
unattainable. Every advance, every discovery, strengthens a new vision: that of a future where
recovering function and improving quality of life is not only possible, but expected.

If this new horizon sparks questions, concerns, or interest, we are here to support the dialogue and
share what science allows us to imagine today.

Contact us for more information about how we may be able to help you and also answer any questions: Contact Us